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RESEARCH OVERVIEW
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PETER M. CALA, Ph.D.
Professor & Chair |
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Membranes and transport with particular emphasis on Na/H exchange isoform type 1 (NHE1). Cell volume and pH regulation. Biochemical control of NHE1 and NHE1 structure-function relationships. Na/H and Na/Ca exchange in ischemia reperfusion injury. The role of NHE1, in tumor growth and proliferation. |
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LAURA BORODINSKY, Ph.D.
Assistant Professor
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JIE ZHENG, Ph.D.
Assistant Professor |
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Developmental Neuroscience. Spinal cord development and function. Synapse formation. Neuronal differentiation. Axonal pathfindng. We investigate the role of neuronal activity on nervous system development.
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Molecular mechanisms of ion channel function. Using novel fluorescence techniques in combination with electrophysiology, molecular biology, and biochemistry to better understand the channel structure and its dynamic rearrangements that underlie channel activities in cellular signal transduction. |
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WEBSITE |
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FITZ-ROY CURRY, Ph.D.
Professor
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MARTHA E. O'DONNELL, Ph.D.
Professor |
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Microcirculation; capillary transport; biomedical engineering; and theoretical aspects of capillary permeability; quantitative measurement of intracellular calcium; video imaging, fluorescence microscopy.
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The role of brain microvascular endothelial cell and astrocyte Na transporters in cerebral edema formation during ischemic stroke and diabetic ketoacidosis. |
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MICHAEL FERNS, Ph.D.
Associate Professor
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JOHN A. PAYNE, Ph.D.
Professor |
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Cellular and molecular basis of synapse formation during development of the mammalian nervous system. Our work focuses on a signaling factor called agrin and its role in regulating the formation of neuromuscular and interneuronal synapses..
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Cellular physiology of the cation chloride cotransport proteins, including the Na-K-Cl cotransporter (NKCC) and K-Cl cotransporter (KCC). We are particularly interested in the function of these transport proteins in excitable cells, neurons and muscle cells. |
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ALLA F. FOMINA, Ph.D.
Assistant Professor
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JONATHAN WIDDICOMBE, Ph.D.
Professor |
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Exocytosis and endocytosis in T lymphocytes; organization of endocytic compartments in T cells; mechanisms of activation of store-operated Ca2+ channels; regulation of cellular function and Ca2+ homeostasis by store-operated Ca2+ currents.
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Ion and water transport across airway epithelia; cystic fibrosis. |
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YU-FUNG LIN, Ph.D.
Assistant Professor
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Cellular and molecular physiology. Functional modulation of potassium channels and GABAA receptors by post-translational mechanisms such as protein phosphorylation, dephosphorylation, lipid modification and nitrosylation; determination of molecular mechanisms and signaling pathways; neuronal ischemic preconditioning.
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